Job Description

At Roche, you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted, and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop, and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position We advance science so that we all have more time with the people we love. Roche Diagnostics acquired Stratos Genomics ( ) in 2020 for its unique chemistry, Sequencing by Expansion (SBX), supporting high signal-to-noise nanopore sequencing. The Protein Engineering group at Roche Diagnostics Seattle focuses on innovative approaches to improve protein performance in SBX, especially the Xpandomer synthase, a highly evolved DNA polymerase that makes SBX possible. We seek passionate individuals eager to contribute to the success of SBX technology. The Opportunity Research, design, and execute innovative and well-controlled experiments with high attention to detail. Identify and troubleshoot problems creatively. Contribute to defining and achieving project goals on time. Perform data analysis and develop protocols. Maintain accurate and detailed laboratory records. Present findings clearly at group or departmental meetings. Maintain lab cleanliness and organization. Propose and develop process improvements. Who You Are You have at least 2 years of practical experience in computational protein design using advanced tools (structure prediction, generative AI, sequence design), focusing on enzyme design and improvement. You hold a BA/BS degree in Biochemistry, Biophysics, Chemistry, Structural Biology, or have a strong background in protein design, enzymology, or related fields with 5 years of relevant experience. Preferred Qualifications MS degree with 4 years of experience or PhD. Strong bench skills, especially in molecular biology methods with proper controls. Experience in designing and screening protein variant libraries. Technical knowledge of next-generation DNA sequencing. Application Requirements Please include a cover letter addressing: Why do you want to work with us? What is your specific interest in SBX technology, and how would you contribute? The salary range for this position in Seattle, WA, is $81,100 - $150,700. Actual pay depends on experience, qualifications, location, and other factors. A discretionary bonus may be available. Benefits are detailed here . Relocation benefits are not available for this posting. Who We Are Driven by a desire for a healthier future, over 100,000 employees worldwide are dedicated to advancing science and ensuring access to healthcare. Our efforts have resulted in over 26 million treatments and 30 billion tests using our products. We foster creativity and high ambitions to deliver impactful healthcare solutions. Let’s build a healthier future, together. Roche is an equal opportunity employer. We treat all employees and applicants based on merit, qualifications, and competence, without unlawful discrimination. For accommodations during the application process, please contact us through the provided form. About Us #J-18808-Ljbffr F. Hoffmann-La Roche AG

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