At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position We advance science so that we all have more time with the people we love. Roche Diagnostics acquired Stratos Genomics ( : / / / ) in 2020 for its unique chemistry, Sequencing by Expansion (SBX), that supports high signal-to-noise nanopore sequencing. The Protein Engineering group at Roche Diagnostics Seattle is focused on innovative approaches to improve the performance of proteins in SBX, especially the Xpandomer synthase, a highly evolved DNA polymerase that makes SBX possible. We are looking for people who are excited about the significance of our technology, and who want to make SBX successful. The Opportunity : Research, design and execute innovative and well-controlled experiments, with high attention to detail. Identify and troubleshoot problems in creative ways. Contribute to the definition and timely achievement of project goals. Perform data analysis and protocol development. Maintain accurate, detailed and reliable laboratory records. Present findings at group or departmental meetings with clear, organized thinking. Maintain the lab's cleanliness and organization. Develop and propose improved processes to fulfill the above functions. Who You Are : You have a minimum of 2 years practical experience in computational protein design using state of the art design tools (structure prediction, generative AI, sequence design), with a focus on enzyme design and improvement You hold a BA / BS degree in Biochemistry, Biophysics, Chemistry, Structural Biology; or a strong background in protein design, enzymology or similar and 5 years relevant experience Preferred Qualifications MS degree with 4 years of experience or PHD Ideally, you will have : Strong bench skills, particularly executing molecular biology methods with proper controls Demonstrated experience designing and screening protein variant libraries Technical background in next-generation DNA sequencing Required for consideration : A cover letter that addresses the following : Why do you want to work with us? What is your specific interest in SBX technology and how would you contribute? The expected salary range for this position based on the primary location of Seattle, WA is 81,100-150,700 . Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed here : Benefits Relocation benefits are not available for this posting. Who we are A healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact. Let's build a healthier future, together. Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants. #J-18808-Ljbffr Roche
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